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Copper peptides should be avoided by anyone with a known copper allergy, those with active inflammatory skin conditions like a rosacea flare or severe eczema, anyone whose skin barrier is severely compromised, and (until more research is available) those who are pregnant or breastfeeding

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Diversity, function and evolution of genes coding for putative Ni-containing superoxide dismutases

The Th1 branch of the immune system creates both the pro-inflammatory state mentioned previously, and cytokines (pro-inflammatory proteins)